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. Author manuscript; available in PMC: 2020 Jun 13.
Published in final edited form as: J Med Chem. 2019 May 24;62(11):5594–5615. doi: 10.1021/acs.jmedchem.9b00551

Figure 4.

Figure 4

BLI assessment of vascular response to VDA. Left) Heat maps overlaid on photographs of male Copenhagen rat with subcutaneous PC3-DAB2IP-luc human prostate tumor xenograft showing light emission about 20 min after administration of D-luciferin (120 mg/kg) at various times with respect to VDA administration IP. Right) Corresponding dynamic light emission curves acquired over about 30 min following luciferin administration. Blue shows baseline; red about 4 h after VDA and green at 24 h. A) 10 mg/kg compound 69 indicating no vascular perturbation, but increased signal at 24 h consistent with rapid tumor growth. B) 6 h later 40 mg/kg compound 69 was administered to the same rat generating about 95% reduced signal at 4 h, consistent with substantial vascular shutdown and showing substantial recovery by 24 h. C) Four days later 30 mg/kg CA4P was administered to this rat eliciting BLI response similar to the BLI response shown in B.