Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Nicotine-induced CPP and CPA are revealed by separate β2-GABA and β2-DA rescue, respectively. A low dose of acute nicotine (0.35 mg/kg) produced no observable response in control mice, β2-KO mice, and β2-VTA mice. The aversive effects of this dose were revealed when β2* nAChRs were rescued in β2-DA mice, and rewarding effects were revealed with β2* nAChR rescue in β2-GABA mice. Data and error bars represent mean ± SEM. *P < 0.05.
