Fig. 2.

TRI-MP administration preserves the architectural integrity of intragraft tissue components. Representative histology of (A) skin and (B) muscle from hindlimb allografts and naïve limbs (hematoxylin and eosin (H&E) staining). Allograft tissue samples taken from rejecting animals (POD = 38–44) display complete destruction of tissue architecture with dense mononuclear cell infiltration. In contrast, tissue samples taken from TRI-MP–treated grafts (POD > 300) exhibit normal/preserved tissue architecture similar to that of hindlimbs from naïve rats. (Scale bars, 100 μm.)