Table 2.
PID | Gender | Maximum pre-ART viral load,* c/mL | CD4+ nadir, cells/µL | Approximate years of infection before initial ART | Current ART regimen | Total years of ART experience | Years of viral suppression on ART at sampling | Plasma viral load on ART, c/mL | CD4+ on ART, cells/µL |
Patient 1† | Male | 412,033 | 16 | Unknown | TDF, FTC, RTG | 13 | 1.0, not suppressed | <50, 134 | 137, 153 |
1683 | Male | 134,406 | 452 | 2.0 | FTC, TDF, RTV, DRV | 5.7 | 5.4 | <40 | 1,348 |
2669‡ | Male | Unknown | 205 | ≤22.0 | ABC, 3TC, DTG | 5.5 | 4.3 | <40 | 681 |
3162‡ | Male | 171,000 | 147 | 11.0 | RTV, DRV, ABC, DTG, 3TC‡ | 20 | 11.2 | <40 | 558 |
R-09 | Male | 97,000 | 105 | Unknown | EFV, FTC, TDF | 9.8 | 5.3§ | ≤133 | 380 |
Abbott Diagnostics RealTime HIV-1 PCR Assay.
ART failure due to drug resistance (Fig. 4) prior to suppression on new regimen including dolutegravir.
PID R-09 maintained viral suppression ≤133 copies/mL for 5.3 y and <40 copies/mL for 0.9 y prior to sample time point.