Fig. 4.
Hepatocyte-specific Aldh2 deficiency decreases excessive, but not light-to-moderate, alcohol drinking preference and binge-like drinking behavior in mice. (A–C) (Left) Mice were subjected to a 2-bottle choice paradigm, and consumption of regular drinking water and ethanol-containing water were measured daily. (A) Alcohol preference is represented as the percentage drank from the alcohol-containing bottle relative to cumulated water and alcohol drinking volumes. (B) Volumes drank from the alcohol-containing bottle per day per gram body weight. (C) Absolute alcohol intake per day per gram body weight. (Right) For all measurements in A−C, the relative area under the curve. (D) A DID was used to study binge-like drinking behavior of Aldh2f/f, Aldh2Hep−/−, B6N, and Aldh2−/− mice. Data are represented as mean ± SEM (n = 5 to 7 mice per group). *P < 0.05, ***P < 0.005, 1-way ANOVA.