Fig. 5.

Forebrain neuron or glial cell targeted Aldh2 deficiency does not affect alcohol drinking preference. Forebrain neuron- (Aldh2^{Camk2a−/−}) and glial cell-specific (Aldh2^Gfap−/−) Aldh2-deficient mice were subjected to the 2-bottle paradigm. (A and D) Alcohol preference and (B, C, E, and F) alcohol intake were evaluated in Aldh2^{Camk2a−/−} and Aldh2^Gfap−/− mice, respectively. Data are represented as mean ± SEM (n = 5 mice per group), unpaired Student’s t test (in C and F).