4.

MiR-27b-3p介导circRNA_005647调控CFs中纤维化相关基因表达

miR-27b-3p mediates the effect of circRNA_005647 on the expressions of fibrosis-related genes in the CFs. A:The predicted binding sites of miR-27b-3p in circRNA_005647; B:Identification of the interaction between miR-27b-3p and circRNA_005647 by dual luciferase assay; C:miR-27b-3p is pulled down in CF lysate by biotin-labeled circRNA_005647 probe detected by RT-qPCR; D: Pulldown of circRNA_005647 by miR-27b-3p detected by RT-qPCR; E:miR-27b-3p enhances the protein expression of fibrosisrelated genes in the CFs; F:miR-27b-3p reverses the effect of circRNA_005647 on protein expression of fibrosis-related genes in the CFs. *P < 0.05, **P < 0.01, ***P < 0.001 (n=3).