Table 5.
Evaluation of Curative Activity of N. Congesta Leaf Extract and Aqueous Fraction
| Ex/Fr | Dose (mg/kg) | Parasitemia Level | PCV | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| D4 | D5 | D6 | D7 | %Supp | Survival Days | D3 | D7 | Change | ||
| CE | 500 | 18.50±3.61 | 60.25±6.27b*** | 84.33±3.28b*** | 85.00±00b*** | 10.05 | 7.00±0.00b*** | 52.25±1.37 | 43.00±2.00 | −18.13±1.47b*** |
| 750 | 12.64±0.61 | 54.20±7.22b*** | 72.25±8.71b*** | 74.66±11.86 | 20.99 | 7.60±0.50b*** | 51.80±0.66 | 44.33±0.88 | −14.73±0.40b*** | |
| 1,000 | 15.27±0.67 | 36.55±3.47b*** | 60.00±10.63 | 51.50±9.5 a*b*** | 45 | 8.70±0.62a*b*** | 50.75±1.25 | 44.00±1.00 | −13.09±2.74b*** | |
| AQf | 200 | 12.37±0.28 | 46.82±5.85b*** | 65.50±8.42 | 75.87±5.96 b*** | 19.70 | 7.25±0.25b*** | 51.75±0.85 | 41.75±0.85 | −19.32±0.77b*** |
| 400 | 10.18±1.44 | 40.60±3.41b*** | 56.25±5.28a*b*** | 64.50±3.50a* b*** | 31.17 | 7.60±0.60b*** | 52.20±0.66 | 43.50±0.50 | −16.34±0.96b*** | |
| 600 | 11.70±0.47 | 40.16±2.45b*** | 46.10±2.10a**b*** | 58.50±5.48a**b*** | 38 | 8.75±0.94a*b*** | 52.75±0.75 | 45.00±1.15 | −14.03±0.83b*** | |
| CQ | 25 | 14.25±4.66 | 2.50±0.64a*** | 0 | 0 | 100 | 30.00±0.00a*** | 51.00±0.70 | 56.50±1.04 | 10.91±3.45a*** |
| DW | 10 | 17.40±2.18 | 57.80±3.36b*** | 88.00±1.00 | 94.50±1.50 | 0 | 6.60±0.24b*** | 51.40±0.67 | 40.00±10 | −23.01±3.40b*** |
Notes: Values are presented as mean±SEM; n=5. a compared to negative control, b compared to positive control. Values are significant at P<0.05, *P<0.05, **P<0.01, ***P<0.001.
Abbreviations: Ex/Fr, Extract/Fraction; DW, Distilled Water (negative control); CQ, Chloroquine (positive control); CE, Crude Extract; AQf, Aqueous fraction; PCV, Packed Cell Volume; D3, Day 3 (after infection); D4, Day 4 (post-treatment); D5, Day 5 (post-treatment); D6, Day 6 (post-treatment); D7, Day 7 (post-treatment); %Supp, % parasitemia suppression.