Fig. 4.

Cross-talk between p53 and Myc pathways. TLR; Toll-like receptors; MYD88: myeloid differentiation factor 88; TRAF6: tumor necrosis factor receptor associated factor 6; BCR: B-cell receptors; SYK: spleen tyrosine kinase; BTK: Bruton's tyrosine kinase; CD: cluster of differentiation; IRS: insulin receptor substrate; PI3K: phosphatidylinositol 3′-kinase; NF-κB: nuclear factor-κB; EBNA: Epstein–Barr virus nuclear antigen; EBV: Epstein–Barr virus; KLF4: Krueppel-like factor 4; FOXM1: forkhead box protein M1; miR: micro RNA; ARF: adenosine diphosphate-ribosylation factor; MDM2: mouse double minute 2 homolog; MDM4: mouse double minute 4 homolog; Sirt1: Sirtuin 1; mTORC1: mammalian target of rapamycin complex 1; mTORC2: mammalian target of rapamycin complex 2.