Table 2.
Expression and prognoses of p53 and Myc in GCB and non-GCB subtype of diffuse large B-cell lymphoma.
| Items | Authors/published time | p53 and/or Myc expression (cut-off value) | Total, positive/evaluated, n (%) | GCB, positive/evaluated, n (%) | Non-GCB, positive/evaluated, n (%) | OS, months | |
|---|---|---|---|---|---|---|---|
| p53 | Xie et al/201458 | p53 (none) | 8/85 (9.4) | 4/46 (8.7) | 4/39 (10.3) | 88 ± 12a | |
| p53− (<30%) | 42/85 (49.4) | 22/46 (47.8) | 20/39 (51.3) | 57 ± 13a | |||
| p53+ (≥30%) | 27/85 (31.8) | 17/46 (37.0) | 10/39 (25.6) | 74 ± 9a | |||
| p53 (diffuse) | 8/85 (9.4) | 3/46 (6.5) | 5/39 (12.8) | 50 ± 18a | |||
| Wang et al/20177 | p53+ (≥50%) | 67/201 (33.3) | NA | NA | 40b | ||
| p53− (<50%) | 134/201 (66.7) | NA | NA | 110b | |||
| Myc | Ye et al/201657 | Myc+ (>70%) | 249/825 (30.2) | 121/430 (28.1) | 127/390 (32.6) | NA | |
| Xu-Monette et al/201559 | Myc+ (>70%) | 175/535 (32.7) | 76/272 (27.9) | 98/259 (37.8) | NA | ||
| Myc− (<70%) | 360/535 (67.3) | 196/272 (72.1) | 161/259 (62.2) | NA | |||
| Xie et al/201458 | Myc+ (≥40%) | 23/85 (27.1) | 9/46 (19.6) | 14/39 (35.9) | 57 ± 11a | ||
| Myc− (<40%) | 62/85 (72.9) | 37/46 (80.4) | 25/39 (64.1) | 69 ± 9a | |||
| Myc/p53 | Wang et al/20177 | p53+ (≥50%), MYC-R | 23/67 (33.8) | NA | NA | 7.4b | |
| p53+ (≥50%), Myc+ (≥40%), | 47/67 (70.1) | NA | NA | 20b | |||
| p53− (<50%), MYC-R | 33/134 (24.6) | NA | NA | 67b | |||
| p53− (<50%), Myc+ (≥40%), | 59/125 (47.2) | NA | NA | 67b | |||
| Myc+, p53+ | Xu-Monette et al/201559 | Myc+ (>70%), TP53 (MUT) | 39/473 (8.2) | 23/239 (9.6) | 16/231 (6.9) | NA | |
| Xie et al/201458 | Myc+ (>40%), p53+ (>30%) | 16/85 (18.8) | 4/46 (8.7) | 12/39 (30.8) | NA | ||
| Myc+, p53− | Xu-Monette et al/201559 | Myc+ (>70%), TP53 (WT) | 114/473 (24.1) | 43/239 (18.0) | 71/231 (30.7) | NA | |
| Xie et al/201458 | Myc+ (>40%), p53− (<30%) | 7/85 (8.2) | 5/46 (10.9) | 2/39 (5.1) | NA | ||
| Myc−, p53+ | Xu-Monette et al/201559 | Myc− (<70%), TP53 (MUT) | 68/473 (14.4) | 42/239 (17.6) | 26/231 (11.3) | NA | |
| Xie et al/201458 | Myc− (<40%), p53+ (>30%) | 19/85 (22.4) | 16/46 (34.8) | 3/39 (7.7) | NA | ||
| Myc−, p53− | Xu-Monette et al/201559 | Myc− (<70%), TP53 (WT) | 252/473 (53.3) | 131/239 (54.8) | 118/231 (51.1) | NA | |
| Xie et al/201458 | Myc− (<40%), p53− (<30%) | 43/85 (50.6) | 21/46 (45.7) | 22/39 (56.4) | NA | ||
GCB: germinal center diffuse large B cell lymphoma; Non-GCB: non-germinal center diffuse large B cell lymphoma; MYC-R: MYC-rearrangement; MUT: mutation; WT: wild type; OS: overall survival; NA: not available.
a
Mean ± SE. SE: standard error.
b
Median.