Table 1:
Clinical and histologic features of U.S. melanoma-prone families
| Non-carriers | CDKN2A carriers | CDK4 carriers | CDKN2A carriers vs. Non-carriers | CDK4 carriers vs. Non-carriers | CDK4 carriers vs. CDKN2A carriers | ||||
|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | P-value | P-value | P-value | |
| Total patients | 104 | 100% | 141 | 100% | 15 | 100% | |||
| Female patients | 49 | 47% | 70 | 50% | 8 | 53% | 0.701 | 0.651 | 0.791 |
| Median age of first melanoma diagnosis (range) | 45 (18–95) | 31 (10–69) | 35 (24–64) | <0.0012 | 0.0032 | 0.212 | |||
| Average number of melanomas per patient (range) | 1.5 (1–6) | 2.5 (1–30) | 3.6 (1–13) | ||||||
| Total melanomas | 157 | 100% | 348 | 100% | 54 | 100% | |||
| Histologic Subtype | <0.0013 | <0.0013 | 0.113 | ||||||
| Acral Lentiginous Melanoma |
1 | 0.6% | 1 | 0.3% | 0 | 0% | |||
| Lentigo Maligna Melanoma |
17 | 11% | 9 | 3% | 0 | 0% | |||
| Nodular Melanoma | 12 | 8% | 14 | 4% | 0 | 0% | |||
| Superficial Spreading Melanoma |
94 | 60% | 275 | 79% | 51 | 94% | |||
| Not Otherwise Specified |
33 | 21% | 49 | 14% | 3 | 6% | |||
1
Chi-square test comparing differences in gender (female vs. male) between groups
2
Wilcoxon-Mann-Whitney test comparing differences in median age of first melanoma diagnosis between groups
3
Fisher exact test comparing overall differences in histologic subtype between groups