Table 3:
Location of first melanoma diagnosis: Comparison of U.S. melanoma-prone families to Surveillance, Epidemiology, and End Results (SEER) data
| Non-carriers |
CDKN2A carriers |
CDK4 carriers | SEER cases (1973–2015) | SEER cases vs. Non–Carriers | SEER cases vs. CDKN2A carriers | SEER cases vs. CDK4 Carriers | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | N | % | P-value | P-value | P-value | |
| Total patients | 104 | 100% | 141 | 100% | 15 | 100% | 313,237 | 100% | |||
|
Female patients |
49 | 47% | 70 | 50% | 8 | 53% | 137,931 | 44% | 0.521 | 0.331 | 0.561 |
|
Median age of diagnosis (range) |
45 (18–95) |
31 (10–69) |
35 (24–64) |
62 (1–87) |
<0.00012 | <0.00012 | <0.00012 | ||||
|
Total melanomas4 |
117 | 100% | 161 | 100% | 24 | 100% | 313,237 | 100% | |||
| Anatomic Site | 0.043 | 0.243 | 0.103 | ||||||||
| Trunk | 65 | 56% | 70 | 44% | 5 | 21% | 111,660 | 36% | |||
| Lower extremities |
16 | 14% | 31 | 19% | 6 | 25% | 61,229 | 20% | |||
| Upper extremities |
22 | 19% | 33 | 21% | 9 | 38% | 83,336 | 27% | |||
| Head and neck | 14 | 12% | 27 | 17% | 4 | 17% | 57,012 | 18% | |||
1
Chi-square test comparing differences in gender (female vs. male) between groups
2
Wilcoxon-Mann-Whitney test comparing differences in median age of first melanoma diagnosis between groups
3
Global p-value adjusting for age at diagnosis, gender, and superficial spreading melanoma subtype
4
Analysis restricted to first primary melanomas for non-carriers, CDKN2A carriers, and CDK4 carriers. Some noncarriers (N=8), CDKN2A carriers (N=15), and CDK4 carriers (N=4) were diagnosed with multiple melanomas at the time of their first melanoma diagnosis.