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. 2019 Nov 2;19:97–108. doi: 10.1016/j.omtn.2019.10.028

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© 2019 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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EZH2 Regulates BRCA1 Expression Independent of Methyltransferase Activity

(A) The enrichment of EZH2 in the promoter region of BRCA1 detected by ChIP. (B) The enrichment of H3K27me3 in the promoter region of BRCA1 detected by ChIP. (C) The enrichment of EZH2 in the intron region of BRCA1 analyzed by microarray-based analysis. (D) The expression of BRCA1 normalized to GAPDH in skeletal muscle cells treated with GSK126 and EPZ6438 (inhibitor of K3K27me3) determined by western blot analysis. The statistical values were measurement data and are expressed as mean ± SD; the data between two groups were analyzed with an independent samples t test. The experiment was repeated three times independently.