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General mechanism of viral membrane fusion and its inhibition for “class I” (α-helical) glycoproteins. The NHR and CHR are indicated and colored cyan or dark blue in both panels. (A) SU, surface subunit (GP1 in MARV); TM transmembrane subunit (GP2 in MARV), FP/FL, fusion peptide/fusion loop. (B) Post-fusion structures of ectodomains from HIV-1 gp41, EBOV GP2, and MARV GP2.
