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. 2019 Nov 12;19:84–96. doi: 10.1016/j.omtn.2019.10.034

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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GAS5 Inhibits the Transcriptional Expression of ABCA1 by Binding to EZH2

(A) Interaction between GAS5 and EZH2 verified by RNA pull-down assay. (B) The enrichment of GAS5 by EZH2 assessed using RIP assay. (C) The effect of GAS5 on ABCA1 gene transcriptional expression assessed using qRT-PCR. (D) Transfection efficiency of sh-EZH2 and the effect of EZH2 on the transcriptional expression of ABCA1 gene determined using qRT-PCR. (E) Expression of EZH2 enriched by ABCA1 detected using ChIP. (F) ABCA1 expression enriched by H3K27me3 detected using ChIP assay. *p < 0.05 versus the IgG group or the sh-NC group; #p < 0.05 versus the pLV-FGFP-N group. Cellular experiment was repeated 3 times. Comparison between two groups was analyzed using t test and comparison among multiple groups was analyzed using one-way ANOVA.