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. 2019 Dec 19;13(2):125–134. doi: 10.1016/j.tranon.2019.10.019

Figure 6.

Figure 6

LDN prolongs the overall survival of mice with intracranialIDH1Mutgliomas. (A) LDN treatment significantly prolonged the overall survival of mice with intracranial IDH1Mut gliomas. Log-rank test. (B) H&E staining of mice brains in DMSO (n = 9) and LDN (n = 9) groups. The medium survival (MS) of DMSO-treated mice was 78 days, and the MS of LDN-treated mice was 94 days. Scale bar: 2 mm. (C) IHC staining of p-Smad1/5 and Id1 in mice brains. p-Smad1/5 localized in nucleus and Id1 localized in both of cytoplasm and nucleus. Scale bar: 50 μm. The expression of p-Smad1/5 and Id1 was decreased under the treatment of LDN. (D) IHC staining of c-Myc and Axin2 in mice brains. c-Myc localized in nucleus and Axin2 localized in cytoplasm. Scale bar: 50 μm. The expression of c-Myc and Axin2 was inhibited under the treatment of LDN. **P < 0.01.