Table 3.
Telomere length interactions with CSF AD biomarkers on cognition
| Outcome | Model | β |
SE |
DF |
P value |
β |
SE |
DF |
P value |
β |
SE |
DF |
P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Aβ-42 interaction | Aβ-42 positive | Aβ-42 negative | |||||||||||
| Executive function | longitudinal | 1.46E-06 | 3.99E-07 | 2035 | .0003* | −0.0001 | 3.52E-05 | 1168 | .0006* | 5.92E-06 | 2.12E-05 | 866 | .7799 |
| Memory performance | longitudinal | 5.86E-07 | 3.04E-07 | 2059 | .0540 | −3.66E-05 | 2.59E-05 | 1189 | .1583 | 2.12E-05 | 1.62E-05 | 869 | .1903 |
| Executive function | cross-sectional | 3.10E-06 | 1.77E-06 | 474 | .0802 | −6.52E-05 | 0.0001 | 294 | .6287 | 4.96E-05 | 0.0001 | 178 | .7072 |
| Memory performance | cross-sectional | 2.68E-06 |
1.58E-06 |
475 |
.0908 |
−8.48E-05 |
0.0001 |
295 |
.4768 |
−6.01E-05 |
0.0001 |
178 |
.6283 |
| Tau interaction |
Tau positive |
Tau negative |
|||||||||||
| Executive function | longitudinal | −1.79E-06 | 4.44E-07 | 1952 | 5.86E-05* | −0.00021 | 4.86E-05 | 603 | 1.46E-05* | −2.73E-05 | 2.14E-05 | 1348 | .2030 |
| Memory performance | longitudinal | −6.38E-07 | 3.40E-07 | 1976 | .0611 | −7.34E-05 | 3.64E-05 | 616 | .0443 | 6.87E-06 | 1.71E-05 | 1359 | .6881 |
| Executive function | cross-sectional | −4.54E-06 | 1.87E-06 | 455 | .0156 | −0.00021 | 0.0002 | 158 | .3152 | −7.17E-06 | 0.0001 | 295 | .9480 |
| Memory performance | cross-sectional | −1.45E-06 | 1.64E-06 | 456 | .3759 | −0.00011 | 0.0002 | 159 | .5303 | −0.0001 | 9.57E-05 | 295 | .2853 |
NOTE. Boldface indicates P values less than .05. Asterisks indicate models that survived Bonferroni correction for eight tests.
Abbreviations: β, beta; SE, standard error; DF, degrees of freedom; Aβ-42, β-amyloid-42.