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Base excision repair of oxidative DNA damage. The presence of 8-oxo-dG in double strand DNA may be repaired before replication by the concerted activity of OGG1, APE1 and translesion synthesis machinery. Alternatively, MTH1 (the homolog of E.coli mutY) recognizes the adenine introduced by replication and excises it. Upon base excision, DNA damage is repaired through the action of APE1 and translesion synthesis machinery.
