Table 1.
List of genes found upregulated by 8-oxo-dG on their promoters.
| Gene name | Function | Cell type | Inducer | Ref. |
|---|---|---|---|---|
| EDN1 | Vasoconstriction | Endothelial | Hypoxia | [145] |
| HMOX1 | Heme catabolysm | Endothelial | Hypoxia | [145] |
| VEGF | Angiogenesis | Endothelial | Hypoxia | [145] |
| BCL2 | Apoptosis regulation | breast cancer | Estrogen | [131] |
| TTF1 | Secreted protein | Breast cancer | Estrogen | [151] |
| KLK3 | Serine protease | Prostate epithelial | Androgen | [152] |
| TMPRSS2 | Serine protease | Prostate epithelial | Androgen | [152] |
| MIR125B2 | Proliferation regulation | Prostate epithelial | Androgen | [152] |
| MIR133B | Apoptosis regulation | Prostate epithelial | Androgen | [152] |
| NCL | Ribosomes synthesis | Fibroblast | Myc | [153] |
| CAD | Pyrimidine biosynthesis | Fibroblast | Myc | [153] |
| CXCL2 | Immunoregulation | Lung epithelial | TNFα | [155] |
| IL1B | Immunoregulation | Lung epithelial | TNFα | [155] |
| TNF | Immunoregulation | Lung epithelial | TNFα | [155] |