Table 1.
Behavioral measures from uninjured (naïve) wild-type and EPAC2−/− mice.
| Behavioral test | Wild-type | EPAC2−/− | P value | Test |
|---|---|---|---|---|
| Von Frey (g) | 2.5 ± 0.3 (18) | 3.1 ± 0.5 (11) | 0.281 | MW |
| Hargreaves (s) | 9.3 ± 0.5 (18) | 8.2 ± 0.4 (11) | 0.159 | t-test |
| Rotarod (s) | 171.5 ± 18.3 (16) | 138.3 ± 14.2 (7) | 0.274 | t-test |
| Activity box average velocity (cm/min) | 41.8 ± 3.4 (16) | 39.7 ± 2.1 (7) | 0.699 | t-test |
| Time on open arms of EPM (s) | 184.1 ± 10.6 (16) | 174.5 ± 25.5 (7) | 0.867 | MW |
| Mechanical conflict (MC) test | ||||
| Number of crossings | 8.7 ± 0.5 (18) | 9.4 ± 1.2 (11) | 0.585 | t-test |
| Time on probes (s) | 40.6 ± 4.3 (18) | 42.4 ± 5.4 (11) | 0.805 | t-test |
| Latency to 1st crossing (s) | 38.9 ± 5.6 (18) | 42.0 ± 8.6 (11) | 0.875 | MW |
| Latency to 2nd crossing (s) | 52.1 ± 6.1 (18) | 57.5 ± 9.5 (11) | 0.822 | MW |
Behavioral tests were run before surgery on naïve WT and EPAC2−/− female mice. Each value is the mean ± SEM (number of mice tested). Tests: paired t-test (t-test) and non-parametric Mann Whitney U test (MW). EPM, elevated plus maze.