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. 2019 Dec 4;7:100038. doi: 10.1016/j.ynpai.2019.100038

Fig. 3.

Fig. 3

Genetic profiling analysis. (A) Heat map of 33 differentially expressed genes from saliva of injury patients vs. control subjects. Supervised analysis of gene profiling data from ankle injury patients and control subjects. The genes with multiple test corrected p value <0.05 and absolute change >2 folds were considered significantly and differentially expressed. In each heat map, rows depict differentially expressed genes and columns depict individual subjects. The relative expression level of genes is shown using a pseudocolor scale from −3 to +3 (green represents down regulation and red represents up regulation). (B) Pathways enrichment analysis of genes that are differentially expressed in saliva from ankle injury patients compared to controls. This analysis depicts the significant effect on multiple stress and inflammation pathways including DNA Damage, Neuroinflammation, AMPK and ATM signaling. Pathways with multiple test corrected p value <0.05 were considered significant. (C) Top regulatory molecules (orange) significantly altered in injury group as compared to controls. Lines ending in an arrow represent amplification and those ending in a flat line represent an inhibitory connection. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)