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. 2019 Dec 17;204(1):68–77. doi: 10.4049/jimmunol.1900941

FIGURE 5.

FIGURE 5.

Tregs express lower levels of the transcription factor Helios, and their frequency is inversely correlated with gestational age in ELBW preterm infants. Relative proportions of (A) total Tregs (CD25+FOXP3+CD127) and (B) the frequencies of CD45RA+ and CD45RA Tregs are shown. (C and D) Expression level of (C) CTLA4 among all Tregs and frequencies of (D) CD45RA+ and CD45RA cells within CTLA4+ Tregs. (E) The level of Helios expression among Tregs and (F) the frequencies of CD45RA+ and CD45RA cells within Helios+ Tregs. Bars show medians with interquartile ranges. Kruskal-Wallis test with Dunn multiple comparison tests was used to make group comparisons. (G) Correlation between Treg percentages from ELBW neonates at D14 and the gestational age at birth.