FIGURE 6.

CD4⁺ T cells and Tregs from 14-d-old ELGAN/ELBW preterm infants have a markedly altered homing capacity. The frequencies of (A and D) CCR4⁺, (B and E) α4β7⁺, and (C and F) CCR9⁺ within total (A–C) CD4⁺ T cells and (D–F) Tregs, respectively, are shown. Bars show medians with interquartile ranges. Kruskal-Wallis test with Dunn multiple comparison tests was used for group comparisons. (G) PCA of the influence of gestational age on the frequencies of CCR4-, CCR9- and α4β7-expressing CD4⁺ T cells and Tregs at D14 in the ELBW (color) neonates. FT infants (black) are shown as a reference.