FIGURE 7.

Chorioamnionitis and NEC affect the Tregs and CD4 T cells, respectively, whereas no association of cause and effect of sepsis is observed on T cell compartment. PCA plot of the proportions of (A) total, CD4⁺, and CD8⁺ lymphocytes and their ratio and (B and C) frequencies of CCR4⁺, CCR9⁺, and α4β7⁺ CD4⁺ T cells and Tregs at D14 from ELBW neonates in sepsis and NEC cases, respectively. The infants were grouped according to if the sepsis/NEC onset was before or after the sample was collected at 14 d of life. (D) Proportions of CCR9⁺ CD4 T cells in ELBW neonates at D14 of life in NEC cases. Frequencies of (E) total CD4⁺ T cells, (F) Tregs, (G) CTLA4⁺, and (H) Helios⁺ Tregs at D14 for ELGAN/ELBW infants from chorioamnionitis cases. Scatter plots show medians with interquartile ranges. Mann-Whitney U test was used for group comparisons.