Table 4.
Effect of EASPA on serum haematological parameters in the subacute toxicity study.
| Parameters | Unit | Control | 1.75 mg/kg | 3.5 mg/kg | 7 mg/kg | 14 mg/kg |
|---|---|---|---|---|---|---|
| WBC | 109/L | 6.20 ± 1.61 | 5.60 ± 0.56 | 6.40 ± 0.53 | 7.20 ± 0.35 | 5.50 ± 0.04 |
| RBC | 1012/L | 6.12 ± 0.32 | 6.89 ± 0.08 | 6.24 ± 0.21 | 6.66 ± 0.10 | 6.20 ± 0.13 |
| Haemoglobin | g/dL | 11.70 ± 0.37 | 12.80 ± 0.68 | 12.90 ± 0.49 | 13.40 ± 0.17 | 13.00 ± 0.08 |
| Haematocrit | % | 33.10 ± 1.46 | 37.00 ± 0.47 | 34.90 ± 1.47 | 35.90 ± 0.40 | 34.60 ± 0.71 |
| MCV | fL | 109.43 ± 0.78 | 107.45 ± 0.49 | 111.70 ± 0.93 | 107.80 ± 0.44 | 111.60 ± 0.17 |
| MCH | pg | 19.55 ± 0.86 | 20.10 ± 0.14 | 20.30 ± 0.28 | 20.20 ± 0.08 | 21.00 ± 0.62∗ |
| MCHC | g/dL | 35.8 ± 1.25 | 37.42 ± 0.53 | 36.95 ± 0.31 | 37.3 ± 0.17 | 37.65 ± 1.02∗ |
| PLT | 109/L | 558.07 ± 109.03 | 495.33 ±74.24 | 522.00 ± 10.7 | 431.00 ± 69.3 | 535.00 ± 17.4 |
| Lymphocytes | 109/L | 5.5 ± 0.20 | 5.87 ± 0.21 | 5.90 ± 0.49 | 5.70 ± 0.45 | 5.1.00 ± 0.04 |
| Monocytes | 109/L | 0.37 ± 0.06 | 0.40 ± 0.05 | 0.30 ± 0.04 | 0.30 ± 0.04 | 0.20 ± 0.00 |
| Granules | 109/L | 0.20 ± 0.00 | 0.26 ± 0.02 | 0.20 ± 0.00 | 0.20 ± 0.00 | 0.20 ± 0.00 |
| RDW-CV | % | 23.90 ± 0.54 | 23.75 ± 0.19 | 23.40 ± 0.26 | 23.70 ± 0.31 | 23.30 ± 0.13 |
| MPV | fL | 10.60 ± 0.12 | 10.40 ± 0.20 | 10.00 ± 0.26 | 10.00 ± 0.08 | 10.10 ± 0.13 |
| PCT | % | 0.30 ± 0.05 | 0.25 ± 0.03 | 0.26 ± 0.01 | 0.21 ± 0.03 | 0.26 ± 0.00 |
Values are expressed as a mean ± SEM (n = 6, p < 0.05, and ∗ = significant difference from the control group).
RBC: Total red blood cell count; WBC: total white blood cell count; PLT: platelet count; MCV: mean corpuscular volume; MCH: mean corpuscular haemoglobin; MCHC: mean corpuscular haemoglobin concentration; RDW-CV: red blood cell distribution width; MPV: mean platelet volume; PCT: procalcitonin.