Table I.
Ribotype | RT220 Total (%) |
RT002 + RT015 Total (%) |
All other ribotypes Total (%) |
P-valueb |
---|---|---|---|---|
Demographic data | ||||
No. of C. difficile episodes with ribotyped isolates (N=705) | 23 (3.3) | 159 (22.6) | 523 (74.2) | |
Total no. of unique patients (N=672) | 21 (91.3) | 153 (96.2) | 498 (95.2) | 0.57 |
Age range of C. difficile episodes (years) | ||||
<65 | 4 (17.4) | 45 (28) | 165 (31.5) | 0.17 |
65–79 | 13 (56.5) | 54 (33.9) | 168 (32.1) | |
>80 | 6 (26.1) | 60 (37.7) | 190 (36.3) | |
Female sex, N (%) | 17 (73.9) | 80 (50.3) | 288 (55.1) | 0.1 |
Sample source (N, %) | ||||
Hospital | 19 (82.6) | 131 (82.4) | 453 (86.6) | 0.39 |
General practice | 4 (17.4) | 28 (17.6) | 70 (13.4) | |
Median Elixhauser score (% with data available) | 6.70 (56.5) | 6.75 (57.2) | Data not available | 0.95 |
Descriptives | ||||
Hospital-onset episodes N/total with data available (%) | 11/22 (50) | 73/141 (51.8) | 244/446 (52.3) | 0.95 |
Toxin EIA positivea, N (%) | 14/21 (63.6) | 43/98 (43.9) | 132/319 (41.3) | 0.08 |
Speciality, N (%) | ||||
Medicine | 10 (43.5) | 83 (52.2) | 259 (49.5) | 0.69 |
Surgery | 5 (21.7) | 23 (14.5) | 95 (18.2) | |
General practice | 4 (17.3) | 28 (17.6) | 70 (13.4) | |
Other | 4 (17.3) | 25 (15.6) | 99 (18.9) | |
Biomarkers, median (range) | ||||
CRP (mg/L) | 173 (36–319) | 44 (1–358) | 99 (1–364) | <0.008 |
Leukocytes (x109/L) | 15.0 (6.5–22) | 11.2 (2.5–30.3) | 11.0 (0.3–51.4) | 0.22 |
Albumin (g/L) | 17.5 (11–24) | 23 (12–36) | 23 (11–48) | 0.07 |
Creatinine (μmol/L) | 98.5 (39–229) | 80 (38–225) | 68 (30–660) | 0.36 |
Outcome | ||||
Length of hospital stay (days) in 30-day survivors, mean (±SD) | 15.8 (±20.8) | 20.2 (±21.9) | 22.7 (±29.1) | 0.74 |
Death within 30 days of sampling, N/total with data available (%) | 7/17 (41.2) | 23/105 (21.9) | 60/341 (17.5) | 0.02 |
CRP, C-reactive protein; EIA, enzyme immunoassay; SD, standard deviation.
Data were compared between episodes caused by different ribotypes: RT220, RT002 with RT015, and all other ribotypes.
Toxin EIA testing undertaken from July 2012.
Chi-squared test for categorical variables.