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. 2019 Dec 20;17(4):1559325819895912. doi: 10.1177/1559325819895912

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Real-time polymerase chain reaction study indicates that irradiation significantly upregulates sphingomyelinase phosphodiesterase 1 (SMPD1) gene expression in the experimental control animals with saline injection at 6 weeks after radiation exposure. Pretreatment or posttreatment with amitriptyline significantly reduces SMPD1 gene expression when compared to the experimental control mice. *P < .05 compared to the normal control group, #P < .05 compared to the experimental control group. n = 10 per group.