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. 2019 Dec 17;10:2902. doi: 10.3389/fimmu.2019.02902

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Copyright © 2019 Granja, Perdiguero, Martín-Martín, Díaz-Rosales, Soleto and Tafalla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clustering analysis of differentially expressed genes in TNP-LPS and/or TNP-KLH stimulations related to different immune-relevant groups. Genes were row normalized and hierarchical clustering constructed using Pearson correlation and the average linkage clustering method. Genes were grouped in pattern recognition receptors; tumor necrosis factor family of ligands, receptors, and related proteins; chemokines and chemokines receptors; cytokines, cytokine receptors, and related proteins; and interferon related proteins. Central columns highlight genes showing significant differential expression (FDR p < 0.05) when TNP-KLH was compared to Control (KLHvsC), TNP-LPS to Control (LPSvsC), or TNP-LPS to TNP-KLH (LPSvsKLH).