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. Author manuscript; available in PMC: 2019 Dec 23.
Published in final edited form as: Am J Psychiatry. 2012 Sep;169(9):963–973. doi: 10.1176/appi.ajp.2012.11091423

TABLE 1.

Genotyped Individuals, Families, and Ancestriesa

Affected and Unaffected Subjects and Ancestry
Genotyped Affected
 Genotyped Unaffected
 Families
European
 Other
 European
 Other
 Other
Site N Male N Male N Male N Male Total European Mediterranean Admix1 Admix2 Admix3 Malabar Total
Australia/United States 128 0.63 2 0.50 107 0.49 1 0.00 238 57 1 0 0 0 0 58
Cardiff 43 0.70 2 0.50 30 0.33 2 0.50 77 21 0 0 0 0 0 21
Johns Hopkins 282 0.64 6 0.67 261 0.44 3 0.33 552 122 1 0 0 0 0 123
Illinois/NorthShore 118 0.74 2 1.00 92 0.48 1 0.00 213 53 1 0 0 0 0 54
Paris 53 0.57 99 0.62 37 0.54 83 0.36 272 21 0 11 11 5 8 56
VCU/Ireland 399 0.67 0 — 286 0.43 0 — 685 216 0 0 0 0 0 216
Western Australia/Germany 195 0.52 28 0.57 177 0.47 24 0.50 424 91 12 0 0 0 0 103
Total 1,218 0.64 139 0.61 990 0.45 114 0.39 2,461 581 15 11 11 5 8 631
a

Shown are the number of genotyped affected and unaffected subjects and the proportion of males in each group, and the number of families with each genotypic ancestry (Admix1, Admix2, and Admix3 are admixed European/African families with increasing proportions of African admixture, as shown in Figure S2 in the online data supplement; Malabar refers to La Reunion families of South Indian origin). Subjects were drawn from seven samples previously collected for linkage studies. All families were multiplex (had at least two narrow-diagnosis cases ascertained), but some had only one affected case in the nuclear family that was selected as informative, or because DNA was not available or failed quality control for some cases. Based on power analyses of simulated data to optimize power in relation to cost, analyses included nuclear families with one case and at least one parent, or with two or more cases and zero to two genotyped parents; plus unaffected siblings where available (up to two with no genotyped parents and one with one genotyped parent). The number of affected cases available and selected for genotyping was 1 (102 families), 2 (391 families), 3 (104 families), 4 (20 families), 5 (7 families), 6 (3 families), or 7 (4 families). The primary analysis included the European-ancestry families. Most of the non-European families were from La Réunion Island (Paris VI site) and were included because of large size. VCU=Virginia Commonwealth University.