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. 2019 Dec 12;25:9471–9482. doi: 10.12659/MSM.920319

Figure 5.

Figure 5

TMUB1 suppresses HCC proliferation via regulating STAT1. (A) An EdU assay indicated that the STAT1 interference plasmid rescued the inhibition of TMUB1 on the proliferation of MHCC97h cells. (B) Western blotting detected TMUB1, STAT1 and CCND1 proteins in MHCC97h cells. (C) An EdU assay indicated that the STAT1 overexpression plasmid rescued the promotion of shTMUB1 on the proliferation of Huh7 cells. (D) Western blotting detected TMUB1, STAT1, and CCND1 proteins in Huh7 cells. TMUB1 – transmembrane and ubiquitin-like domain-containing protein 1; HCC – hepatocellular carcinoma; STAT1 – signal transducer and activator of transcription 1; EdU – 5-ethynyl-2′-deoxyuridine.