. Author manuscript; available in PMC: 2019 Dec 23.

Published in final edited form as: J Hypertens. 2018 May;36(5):1094–1103. doi: 10.1097/HJH.0000000000001680

TABLE 1.

Hub genes of the hypertension gene list

Gene name	Gene description	Degree	Betweenness centrality^a	Closeness centrality^a
INS	Insulin	78	0.16	0.60
REN	Renin	70	0.14	0.57
KNG1	Kininogen 1	70	0.11	0.57
ACE	Angiotensin–I– converting enzyme	62	0.05	0.55
GCG	Glucagon	58	0.04	0.54
AGT	Angiotensinogen	52	0.05	0.53
EDN1	Endothelin 1	45	0.02	0.51
NOS3	Nitric oxide synthase 3	44	0.01	0.51
VEGFA	Vascular endothelial growth factor A	42	0.02	0.51
NPY	Neuropeptide Y	40	0.03	0.51

HTNGL, hypertension gene list.

Betweeness and Closeness centralities for the most central HTNGL genes (degree ≥40). Larger numbers indicate more hub-like properties.