Table 3.

Visit Wise Scores Of WOMAC Pain, Stiffness, Physical Function And Total WOMAC Scores

	Visits	Placebo (n=23)			E-OA-07 (n=21)			p value*
		Mean (SD)	95% CI		Mean (SD)	95% CI
Min	Max	Min	Max
Pain	Day 0	14.87 (1.87)	14.06	15.68	14.95 (1.72)	14.17	15.73	0.879
	Day 7	14.87 (2.26)	13.89	15.85	14.86 (2.22)	13.89	15.87	0.985
	p value**	0.952			0.541
	Day 28	14.35 (3.04)	13.03	15.66	12.38 (2.85)	11.08	13.68	0.033
	p value**	0.320			0.003
	Day 56	14.30 (3.81)	12.66	15.95	8.14 (3.84)	6.40	9.89	<0.001
p value**	0.408			<0.001
Stiffness	Day 0	5.17 (1.61)	4.48	5.87	5.38 (1.02)	4.92	5.85	0.618
	Day 7	5.39 (1.37)	4.80	5.99	5.33 (1.16)	4.81	5.86	0.881
	p value**	0.305			0.480
	Day 28	5.04 (1.19)	4.53	5.56	4.52 (1.37)	3.90	5.15	0.184
	p value**	0.609			0.009
	Day 56	5.44 (1.62)	4.74	6.14	2.91 (1.51)	2.22	3.59	<0.001
p value**	0.487			<0.001
Physical Function	Day 0	61.83 (8.70)	58.07	65.59	63.71 (6.86)	60.59	66.84	0.431
	Day 7	62.44 (7.48)	59.20	65.67	63.67 (8.14)	59.96	67.37	0.603
	p value**	0.602			1.000
	Day 28	61.04 (9.08)	57.12	64.97	54.76 (10.61)	49.93	59.59	0.040
	p value**	0.519			0.001
	Day 56	63.09 (11.64)	58.05	68.12	39.38 (13.66)	33.16	45.60	<0.001
p value**	0.603			<0.001
Total WOMAC	Day 0	81.87 (11.54)	76.88	86.86	84.05 (8.65)	80.11	87.98	0.486
	Day 7	82.70 (10.27)	78.26	87.14	83.86 (10.72)	78.98	88.74	0.715
	p value**	0.641			0.599
	Day 28	80.44 (12.87)	74.87	86.00	71.67 (14.40)	65.11	78.22	0.039
	p value**	0.495			0.001
	Day 56	82.83 (16.77)	75.57	90.08	50.43 (18.57)	41.97	58.88	<0.001
p value**	0.871			<0.001

Notes: *P, Mann–Whitney U-test; **Wilcoxon signed rank test.

Abbreviations: n, number of participants; SD, standard deviation; CI, confidence interval; Min, minimum; Max, maximum.