Table 4.
Change In WOMAC Subscale Of Pain, Stiffness, Physical Function And Total WOMAC Scores
| Visit | Placebo (n=23) | E-OA-07 (n=21) | p value* | ||||
|---|---|---|---|---|---|---|---|
| Mean (SD) | 95% CI | Mean (SD) | 95% CI | ||||
| Min | Max | Min | Max | ||||
| Pain | |||||||
| Change (Day 7) | 0.00 (1.09) | −0.47 | 0.47 | −0.10 (1.41) | −0.737 | 0.547 | 0.802 |
| Change (Day 28) | −0.52 (2.35) | −1.54 | 0.50 | −2.57 (2.66) | −3.781 | −1.362 | 0.010 |
| Change (Day 56) | −0.57 (3.03) | −1.87 | 0.74 | −6.81 (3.60) | −8.448 | −5.171 | <0.001 |
| Stiffness | |||||||
| Change (Day 7) | 0.22 (0.95) | −0.19 | 0.63 | −0.05 (0.81) | −0.414 | 0.319 | 0.327 |
| Change (Day 28) | −0.13 (1.39) | −0.73 | 0.47 | −0.86 (1.20) | −1.401 | −0.313 | 0.071 |
| Change (Day 56) | 0.26 (1.82) | −0.52 | 1.05 | −2.48 (1.37) | −3.097 | −1.855 | <0.001 |
| Physical function | |||||||
| Change (Day 7) | 0.61 (5.48) | −1.76 | 2.98 | −0.05 (3.54) | −1.66 | 1.57 | 0.643 |
| Change (Day 28) | −0.78 (8.45) | −4.44 | 2.87 | −8.95 (8.87) | −12.99 | − 4.91 | 0.003 |
| Change (Day 56) | 1.26 (12.10) | −3.97 | 6.49 | −24.33 (13.80) | −30.62 | − 18.05 | <0.001 |
| Total WOMAC | |||||||
| Change (Day 7) | 0.83 (6.56) | −2.009 | 3.661 | −0.19 (4.94) | −2.437 | 2.06 | 0.567 |
| Change (Day 28) | −1.44 (11.27) | −6.306 | 3.436 | −12.38 (11.70) | −17.708 | −7.05 | 0.003 |
| Change (Day 56) | 0.96 (16.26) | −6.073 | 7.986 | −33.62 (17.94) | −41.785 | −25.45 | <0.001 |
Note: *P, mixed analysis of variance.
Abbreviations: n, number of participants; SD, standard deviation; CI, confidence interval; Min, minimum; Max, maximum.