Table 2.
Baseline characteristics
| Characteristic | RASwt population | RASwt CMS population | CMS1 | CMS2 | CMS3 | CMS4 |
|---|---|---|---|---|---|---|
| N = 400 | N = 315 | N = 46 | N = 130 | N = 36 | N = 103 | |
| Sex, male, % | 69.9 | 69.2 | 60.9 | 71.7 | 80.6 | 66.0 |
| Age, median, years | 64 | 64 | 59 | 64 | 66 | 65 |
| Site of primary tumor, % | ||||||
| Colon | 61.3 | 62.9 | 76.1 | 66.2 | 58.3 | 54.4 |
| Rectum | 34.8 | 32.7 | 19.6 | 30.8 | 33.3 | 40.8 |
| Colon + rectum | 3.8 | 4.4 | 4.3 | 3.1 | 8.3 | 4.9 |
| Liver metastasis only, yes, % | 33.2 | 34.9 | 37.0 | 40.9 | 22.2 | 32.0 |
| Primary tumor location, % | ||||||
| Right-sided | 22.8 | 22.5 | 41.3 | 15.4 | 19.4 | 24.3 |
| Left-sided | 77.2 | 77.5 | 58.7 | 84.6 | 80.6 | 75.7 |
| Primary resected, yes, % | 85.3 | 88.6 | 95.7 | 89.8 | 66.7 | 94.2 |
| Adjuvant chemotherapy, yes, % | 19.0 | 17.5 | 10.9 | 16.2 | 16.7 | 23.3 |
| ECOG, % | ||||||
| 0 | 53.4 | 52.2 | 45.7 | 56.7 | 52.8 | 49.5 |
| 1 | 45.1 | 46.5 | 54.3 | 41.7 | 47.2 | 48.5 |
| 2 | 1.5 | 1.3 | – | 1.6 | – | 1.9 |
| Synchronous, % | ||||||
| Synchronous | 75.7 | 77.5 | 87.0 | 77.7 | 83.3 | 70.9 |
| Metachronous | 24.1 | 22.2 | 10.9 | 22.3 | 16.7 | 29.1 |
| Unknown | 0.3 | 0.3 | 2.2 | |||
CMS, consensus molecular subgroup; RASwt, rat sarcoma wild-type; ECOG, eastern cooperative oncology group performance status.