Table 2. Univariate and multivariate cox analysis of OS in LUAD and LUSC.
Smoking history: 1. lifelong non-smoker; 2. current smoker; 3. current reformed smoker (for >15 years); 4. Current reformed smoker (for ≤ 15 years); 5. current reformed smoker (duration not specified).
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| pvalue | HR | 95%CI | pvalue | HR | 95%CI | |
| LUAD-OS | ||||||
| Gender Male vs. Female | 0.745 | 1.050 | 0.784-1.405 | |||
| Age >65 vs. ≤65 |
0.229 | 1.198 | 0.892-1.610 | |||
| Smoking history 2∕3∕4∕5 vs. 1 | 0.530 | 0.875 | 0.578-1.325 | |||
| Clinical stage III/IV vs. I/II | 0 | 2.466 | 1.786–3.404 | 0 | 2.329 | 1.682–3.226 |
| ITGA11 expression High vs. Low |
0.076 | 1.306 | 0.973–1.753 | 0.361 | 1.153 | 0.849–1.566 |
| ITGB4 expression High vs. Low |
0.002 | 1.575 | 1.175–2.112 | 0.026 | 1.417 | 1.042–1.926 |
| ITGB8 expression High vs. Low |
0.925 | 0.986 | 0.737–1.320 | |||
| LUSC-OS | ||||||
| Gender Male vs. Female | 0.179 | 1.251 | 0.902–1.736 | 0.177 | 1.253 | 0.903–1.739 |
| Age >65 vs. ≤65 |
0.124 | 1.253 | 0.940–1.670 | 0.049 | 1.343 | 1.001–1.803 |
| Smoking history 2∕3∕4∕5 vs. 1 | 0.430 | 0.698 | 0.286–1.704 | |||
| Clinical stage III/IV vs. I/II | 0.002 | 1.655 | 1.199–2.284 | 0.002 | 1.665 | 1.204–2.301 |
| ITGA11 expression High vs. Low |
0.385 | 1.128 | 0.860–1.479 | |||
| ITGB4 expression High vs. Low |
0.388 | 1.127 | 0.859–1.479 | |||
| ITGB8 expression High vs. Low |
0.875 | 0.978 | 0.746–1.283 | |||