Table 1. Lists of the representative different-expressed pathways and the corresponding affected genes.

Description	BgRatio	Padj	Gene ID
Metabolic pathways	1106/5208	1.16E−16	Cyp2c29/Idi1/Pmvk/Tm7sf2/Gclc/Sqle/Rdh11/Nsdhl/Cyp51/Hmgcs1/Ugdh/Acss2/ Acat2/Msmo1/Me1/Fdft1/Cbs/Qdpr/Sc5d/ Ebp/Acacb/Lipc/Kynu/Lss/Mvd/Acaca/Adh4/Mvk/Coasy/Ddc/Dhcr7/Cyp2c38/ Cyp27a1/Pi4k2b/Aox1/Cyp2j5/Cyp2r1/Aldh1a7/Cyp2c55/Cyp4f14/ Cyp1a2/Tat/Haao/9130409I23Rik/ Cyp3a11/Hibadh/Gldc/Ugt2b36/Sgms2/Pcyt2/Ugt2b5/Idh1/Fdps/ Gbe1/Ndufa4/Csad/Mmab/Comt/Atp5j/Acmsd/Agxt/Cyp2c44/Mdh1/Dhcr24/ Cat/Paics/St3gal3/Slc33a1/Tgds/Scp2/Aldh7a1/Oat/ Akr1c6/Adk/Hsd17b7/Amt/Amdhd1/Pcca/Pon1/Hsd17b2/Acsl5/Ndufv3/Mcee/Hyi/ Lap3/Mat2b/Baat/Enpp3/Cyp2c70/Btd/Adi1/ Cept1/Atp5g1/Gclm/Pik3c3/Cbr3/Gatm/Pipox/ Cox6c/Acly/Otc/Nat2/Glud1/Acss3/Khk/Acsm5/Atp5e
ECM-receptor interaction	84/5208	0.00015843	Cd36/Itga5/Col5a2/Col4a4/Lama5/Sv2a/Col6a1/Lamb2/Col3a1/Col4a1/ Col1a2/Col4a6/Col6a2/Itga3
Protein digestion and absorption	77/5208	0.00016717	Atp1a3/Kcnn4/Col5a2/Col4a4/Slc1a5/Col6a1/Col3a1/Col4a1/Slc7a8/ Col1a2/Col14a1/Col4a6/Col6a2
Leukocyte transendothelial migration	111/5208	0.01246479	Itgb2/Itgam/Cldn14/Cldn15/Actg1/Ezr/Plcg2/Icam1/Pik3r5/Cybb/Ncf1/Ncf2
Focal adhesion	196/5208	0.01246479	Flna/Cav1/Itga5/Col5a2/Col4a4/Lama5/Actg1/Col6a1/Tln1/Lamb2/Col3a1/ Col4a1/Col1a2/Col4a6/Pik3r5/Col6a2/Itga3
Cytokine-cytokine receptor interaction	216/5208	0.02264483	Cxcl1/Ccr1/Csf2rb/Csf2ra/Ccr2/Tnfrsf12a/Inhbe/Lepr/Tnfrsf1b/Kitl/ Clcf1/Pf4/Ccl6/Il6ra/Csf1r/Cxcl14/Tnfrsf11b