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Relationship between the ED50 values of CB1 agonists during agonist drug discrimination (abscissa) and antagonist drug discrimination (ordinate). ED50 values from antagonist drug discrimination were derived from the present studies. ED50 values from agonist drug discrimination of AM2389, AM4054, and Δ9-THC were derived from Kangas et al. (2013) and nabilone, JWH-018, and AM3506 were derived from unpublished studies.
