TABLE 1.

Effects of KRM-II-81 on seizures induced by electrical stimulation of the basolateral amygdala in rats that were seizure kindled in the presence of lamotrigine

KRM-II-81 was given intraperitoneally (1 hour prior to testing) in eight rats. Seizure prevalence was assessed with Fisher’s exact probability test with *P < 0.05 and ** P <0.01 compared with vehicle-treated rats. Seizure severity and duration were evaluated with ANOVA followed by Dunnett’s post-hoc test with * P < 0.05 and ***P < 0.001 compared with vehicle control rats.

KRM-II-81	Rats Protected/Number Tested	Seizure Severity Score (Mean + S.E.M.)	Seizure Duration (Mean + S.E.M.)
(mg/kg)
0	0/8	5.0 ± 0	117.0 ± 13.8
1	0/8	5.0 ± 0	103.0 ± 8.2
5	2/8	4.25 ± 0.49*	123.0 ± 14.8
10	2/8	3.75 ± 0.65***	87.4 ± 10.6***
20	4/8*	3.25 ± 0.59***	106.75 ± 18.7
40	6/8**	2.13 ± 0.52***	66.70 ± 14.0***