TABLE 2.

Effects of KRM-II-81 on seizure outcomes in rats with kainate-initiated chronic epilepsy

Seizure burden data are mean ± S.E.M. for 12 rats. Seizure freedom data are the number of rats that are seizure free/number of rats tested. KRM-II-81 was given three times per day (20 mg/kg, i.p.). *P < 0.05 compared with baseline by Wilcoxon rank sum test (daily seizure burden) or Fisher’s exact probability test (seizure freedom).

Parameter	Baseline	KRM-II-81	Vehicle
Daily seizure burden	6.5 ± 2.9	1.6 ± 0.8*	6.7 ± 3.3
Seizure freedom	1/12	6/12*	2/12