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. 2019 Aug 19;28(21):3543–3551. doi: 10.1093/hmg/ddz200

Table 1.

Summary of pregnancies affected by multiple congenital anomalies (MCA)

Pregnancy Number Cystic hygroma/nuchal translucency Ascites/hydrops Short long bones Cleft Palate Cardiac defect † outcome
MCA 1 + + + ND + IUFD at 21 weeks
MCA 2 + ND + ND ND TOP 12 weeks
MCA 3 + + + ND ND TOP 15 weeks
MCA 4 + + + + (soft) IUFD at 28 weeks

† Ventricular septal defect with possible aortic stenosis and coarctation or hypoplasia of the aortic arch.

IUFD = intra-uterine fetal death; TOP = termination of pregnancy