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. 2019 Dec 16;9:1375. doi: 10.3389/fonc.2019.01375

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Copyright © 2019 Kashima, Tanabe, Tanino, Kobayashi, Murakami, Iwama, Sasaki, Kunogi, Takahashi, Ando, Ueno, Moriichi, Fukudo, Tasaki, Hosokawa, Mizukami, Fujiya and Okumura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Images of computed tomography 1 month after surgery (A–C) and after finish of the nivolumab threatment (D–F). Lymph node metastasis was observed (A) in the subclavicle (#104L, yellow arrowhead), (B) mediastinum (#108L, yellow arrow), and (C) paraaorta (#16b1, red arrow), indicating distally metastatic recurrence of the carcinoma (progressive disease). Lymph node metastasis of (D) the subclavicle (#104L), (E) mediastinum (#108L), and (F) paraaorta (#16b1) had vanished, indicating a complete response.