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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: J Drug Deliv Sci Technol. 2019 Apr 18;52:165–176. doi: 10.1016/j.jddst.2019.04.029

Table 3.

Extrusion conditions and parameters of various polymer/ drug ratio compositions with and without P-CO2 injection

Formulations Processing
Temperature		 Screw
Speed		 Barrel
Torque		 P-CO2
Injection		 P-CO2
(PSI)		 Back
Pressure		 Feeding
Zone		 HME
Process
(°C) (rpm) (%) Zone
 Blockage
4 6 8
100% HPMC-AS LG 140 100 Maximum * - - - - - - Failed
100% HPMC-AS LG 140 75 Maximum - - - - - - Failed
100% HPMC-AS LG 140 100 Maximum √ √ - - High - Failed
100% HPMC-AS LG 140 75 Maximum √ √ - - High - Failed
100% HPMC-AS LG 150 100 Maximum - - - - - - Failed
100% HPMC-AS LG 150 75 Maximum - - - - - - Failed
100% HPMC-AS LG 150 100 Maximum √ √ - - High - Failed
100% HPMC-AS LG 150 75 Maximum √ √ - - High - Failed
100% HPMC-AS LG 160 100 98H.TQ √ √ - - High - Successful**
100% HPMC-AS LG 160 75 88H.TQ √ √ - - High - Successful**
100% HPMC-AS LG 170 100 88-90H.TQ √ √ - - High - Successful**
100% HPMC-AS LG 170 75 82H.TQ √ √ - - High - Successful**
100% HPMC-AS LG 190H.T 100 84-92H.TQ √ √ - - High - Successful**
100% HPMC-AS LG 190H.T 75 80-90H.TQ √ √ - - High - Successful**
100% HPMC-AS LG 190H.T 100 84-92H.TQ - - √ 300-400 Low No Successful**
100% HPMC-AS LG 190H.T 75 80-90H.TQ - - √ 300-400 Low No Successful**
80% HPMC-AS LG/% 20 EFA 140 100 54 - - - - - - Successful
70% HPMC-AS LG/% 30 EFA 140 100 46 - - - - - - Successful
60% HPMC-AS LG/% 40 EFA 140 100 33 - - - - - - Successful
50% HPMC-AS LG/% 50 EFA 140 100 27 - - - - - - Successful
80% HPMC-AS LG/% 20 EFA 150 75 44 - - - - - - Successful
70% HPMC-AS LG/% 30 EFA 150 75 25-30 - - - - - - Successful
60% HPMC-AS LG/% 40 EFA 150 75 20-25 - - - - - - Successful
50% HPMC-AS LG/% 50 EFA 150 75 13-20 - - - - - - Successful
80% HPMC-AS LG/% 20 EFA 140 100 54 - - √ 300-400 Low No Successful
70% HPMC-AS LG/% 30 EFA 140 100 46 - - √ 300-400 Low No Successful
60% HPMC-AS LG/% 40 EFA 140 100 33 - - √ 300-400 Low No Successful
50% HPMC-AS LG/% 50 EFA 140 100 27 - - √ 300-400 Low No Successful
80% HPMC-AS LG/% 20 EFA 150 75 44 - - √ 250-350 Low No Successful
70% HPMC-AS LG/% 30 EFA 150 75 25-30 - - √ 250-350 Low No Successful
60% HPMC-AS LG/% 40 EFA 150 75 20-25 - - √ 250-350 Low No Successful
50% HPMC-AS LG/% 50 EFA 150 75 13-20 - - √ 250-350 Low No Successful
*

The motor load reached the maximum level in which it was impossible to move on.

**

Very limited success to obtain the final product, but with very high motor load and high temperature.

H.T: Very high temperature.

H.TQ: Very high motor load (High Torque).