Table 3:

Subgroup comparisons for the primary outcome (weight changes (kg) from baseline to 6 years) and the secondary outcome (weight exposure or AUC) for participants in Control, Large Changes and Small Changes with covariate adjustment for gender, race/ethnicity, clinic site, and mode of weight measurement (clinic-based or Smart Scale).

Subgroup	Intervention Assignment Mean (SE)			Overall p-value
	Control	Large Changes	Small Changes
Primary Outcome   18 – 24.9 years of age  ≥ 25.0 −35 years of age   Difference [95% CI]      Females   Males   Difference [95% CI]      Non-overweight   Overweight   Difference [95% CI]	7.30 (1.02) 2.97 (0.55) 4.32 [1.55,7.09]* 3.79 (0.54) 4.66 (1.15) −0.87 [−3.92,2.19] 3.46 (0.71) 4.34 (0.67) −0.88 [−3.22,1.46]	3.86 (1.01) 2.44 (0.57) 1.42 [−1.35,4.21] 3.14 (0.56) 1.63 (1.08) 1.51 [−1.40,4.43] 2.27 (0.71) 3.29 (0.69) −1.02 [−3.40,1.35]	3.18 (0.95) 4.52 (0.57) −1.34 [−3.99,1.32] 3.79 (0.56) 5.39 (1.00) −1.60 [−4.35,1.15] 2.54 (0.76) 5.29 (0.64) −2.75 [−5.13,−0.37]*	0.008 0.026 0.002** 0.631 0.029 0.156** 0.46 0.10 0.33**
Secondary Outcome1  18–24.9 years of age  ≥ 25.0 −35 years of age   Difference [95% CI]   Females   Males   Difference [95% CI]      Non-overweight   Overweight   Difference [95% CI]	15.47 (3.79) 5.43 (2.30) 10.04 [2.06,18.02]* 8.88 (2.17) 9.72 (4.08) −0.84 [−9.52,7.83] 4.98 (2.91) 11.11 (2.65) −6.14 [−13.20,0.92]	6.95 (3.45) −3.68 (2.42) 10.64 [2.88,18.40]* 1.77 (2.19) −3.76 (3.90) 5.53 [−2.85,13.91] 0.07 (2.85) −0.87 (2.70) 0.95 [−6.15,8.05]	4.71 (3.47) 3.63 (2.37) 1.08 [−6.51,8.68] 5.91 (2.18) 1.36 (3.99) 4.55 [−3.99,13.09] 3.84 (2.98) 4.40 (2.58) −0.56 [−7.65,6.53]	0.06 0.005 0.15** 0.04 0.04 0.54** 0.37 0.003 0.33**

¹Change in kilogram years over follow-up including weight changes at 4 months, years 1, 2, 3, 4, 4.5, 5, 5.5, and 6 years

^*95% confidence interval excludes 0

^**Interaction p-value