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. 2019 Dec 19;11:10599–10608. doi: 10.2147/CMAR.S222681

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© 2019 Sun et al.

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The effects of LRIG2 knockdown on miR-503 inhibition induced angiogenesis promotion. (A and B) The expression levels of LRIG2 and VEGFA mRNA and protein were measured by qRT-PCR and Western blot assay. (C) LRIG2 knockdown inhibits the enhanced concentration of VEGFA detected by ELISA assay. (D) The HCMEC/D3 cell proliferation ability was measured by the MTT assay in cells with miR-503 inhibitor transfection and miR-503 inhibitor+sh-LRIG2 co-transfection. (E) HCMEC/D3 migration capacity induced by coculture with glioma cells was detected by transwell assay using cocultured system. (F) Angiogenesis ability of HCMEC/D3 cells with miR-503 inhibitor transfection and miR-503 inhibitor + sh-LRIG2 co-transfection was measured. The experiment was repeated for three times. P value was determined by ANOVA following Tukey's post hoc test. Data are the mean ± SD for three independent experiments. *P < 0.05 and **P < 0.01.