TABLE 3.
Patient Baseline Characteristics of the AF and Contraindicated to OAC Cohorts by OAC Status
| No OAC Use (n = 8,283) | OAC Use (n = 12,454) | p Value | |
|---|---|---|---|
| Age, yrs | 81.9 ± 7.5 | 80.0 ± 6.7 | <0.001 |
| Age group | <0.001 | ||
| 65–69 years of age | 540 (6.5) | 900 (7.2) | |
| 70–74 years of age | 915 (11.0) | 1,852 (14.9) | |
| 75–79 years of age | 1,570 (19.0) | 2,936 (23.6) | |
| 80+ years of age | 5,258 (63.5) | 6,766 (54.3) | |
| Female | 5,134 (62.0) | 7,140 (57.3) | <0.001 |
| Race/ethnicity | <0.001 | ||
| White | 7,631 (92.1) | 11,760 (94.4) | |
| Black | 402 (4.9) | 428 (3.4) | |
| Other | 250 (3.0) | 266 (2.1) | |
| Region | <0.001 | ||
| Northeast | 1,945 (23.5) | 3,414 (27.4) | |
| South | 3,265 (39.4) | 4,363 (35.0) | |
| Midwest | 1,878 (22.7) | 2,966 (23.8) | |
| West | 1,195 (14.4) | 1,711 (13.7) | |
| Contraindications | <0.001 | ||
| 1 | 6,223 (75.1) | 10,278 (82.5) | |
| 2 | 1,958 (23.6) | 2,094 (16.8) | |
| 3+ | 102 (1.2) | 82 (0.7) | |
| Contraindication type | |||
| End-stage liver disease | 65 (0.8) | 86 (0.7) | .43 |
| Blood dyscrasia | 6,191 (74.7) | 9,148 (73.5) | .04 |
| Intracranial mass | 237 (2.9) | 320 (2.6) | .20 |
| GI bleed | 3,314 (40.0) | 4,673 (37.5) | <0.001 |
| ICH | 647 (7.8) | 489 (3.9) | <0.001 |
| Comorbid conditions | |||
| Atrial flutter | 833 (10.1) | 1,455 (11.7) | <0.001 |
| Dementia | 1,440 (17.4) | 1,102 (8.8) | <0.001 |
| Diabetes mellitus | 3,422 (41.3) | 5,203 (41.8) | .51 |
| Ischemic heart disease | 5,463 (66.0) | 8,143 (65.4) | .40 |
| Peripheral vascular disease | 3,395 (41.0) | 4,550 (36.5) | <0.001 |
| Congestive heart failure | 4,930 (59.5) | 6,953 (55.8) | <0.001 |
| Cerebrovascular disease | 3,343 (40.4) | 4,491 (36.1) | <0.001 |
| Hypertension | 7,628 (92.1) | 11,370 (91.3) | .04 |
| COPD | 3,871 (46.7) | 5,291 (42.5) | <0.001 |
| Renal disease | 2,533 (30.6) | 3,186 (25.6) | <0.001 |
| Stroke/TIA | 2,501 (30.2) | 3,223 (25.9) | <0.001 |
| Cancer | 2,082 (25.1) | 3,384 (27.2) | .001 |
| Valvular heart disease | 3,756 (45.3) | 6,153 (49.4) | <0.001 |
| CHA2DS2-VASc score | 5.7 ± 1.6 | 5.5 ± 1.6 | <0.001 |
| 2 | 162 (2.0) | 288 (2.3) | .08 |
| 3 | 502 (6.1) | 934 (7.5) | <0.001 |
| ≥4 | 7,619 (92.0) | 11,232 (90.2) | <0.001 |
| CHADS2 score | 3.4 ± 1.4 | 3.2 ± 1.3 | <0.001 |
| 0 | 52 (0.6) | 77 (0.6) | .93 |
| 1 | 550 (6.6) | 1,002 (8.0) | <0.001 |
| ≥2 | 7,681 (92.7) | 11,375 (91.3) | <0.001 |
| Devices in place | |||
| ICD | 336 (4.1) | 753 (6.0) | <0.001 |
| Pacemaker | 1,752 (21.2) | 2,947 (23.7) | <0.001 |
Values are mean ± SD or n (%).
Abbreviations as in Table 1.