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. 2019 Dec 19;12:11305–11311. doi: 10.2147/OTT.S228301

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© 2019 Chen et al.

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The change of Immunohistochemistry. (A) Jan 2016, resistant to AZD9291, indicated SCLC (IHC: NapsinA−, TTF1+, Syn+). (B) Oct 2016, lesion A after resistant to IO, indicated SCLC (IHC: NapsinA-，TTF-1+, Syn-, CD56+). (C) Oct 2016, lesion B after reistance to IO, indicated adenocarcinoma (IHC: NapsinA+,TTF-1+).