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. 2019 Dec 19;12:11241–11254. doi: 10.2147/OTT.S220621

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© 2019 Rao et al.

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Modulation of miR-27a-3p altered GATA6 expression in pancreatic carcinoma cells. (A) MiR-27a-3p could completely bind with the ACUGUGA of GATA6 3ʹ-UTR sequence using TargetScan and PicTar computer-aided algorithms. (B) The expression relationship of GATA6 mRNA and miR-27a-3p in pancreatic carcinoma samples by Spearman correlation. (C and E) The mRNA and protein expression levels of GATA6 were evaluated in AsPC-1 and Panc-1 cells after miR-27a-3p overexpression. (D and F) MiR-27a-3p inhibitor-treated pancreatic carcinoma cells significantly increased GATA6 mRNA and protein expression. *P<0.05.