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. 2019 Dec 19;12:11241–11254. doi: 10.2147/OTT.S220621

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© 2019 Rao et al.

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GATA6 was the direct target gene of miR-27a-3p. PmirGLO luciferase reporter plasmid containing the GATA6 3ʹ-UTR-WT (A) or MUT (B) sequence was constructed to verify the binding site between GATA6 and miR-27a-3p. (C) In pancreatic carcinoma cells, miR-27a-3p overexpression suppressed the relative luciferase activity of GATA6 3ʹ-UTR-WT vector. miR-27a-3p mimic-treated pancreatic carcinoma cells have no influence on the relative luciferase activity of GATA6 3ʹ-UTR-MUT vector. (D) In pancreatic carcinoma cells, miR-27a-3p inhibition augmented the relative luciferase activity of GATA6 3ʹ-UTR-WT vector. miR-27a-3p inhibitor-transfected pancreatic carcinoma cells have no influence on the relative luciferase activity of GATA6 3ʹ-UTR-MUT vector. *P<0.05.