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. 2019 Dec 11;15(12):e1007485. doi: 10.1371/journal.pcbi.1007485

Fig 1. BH3 motif and key positions for Bcl-2/BH3 interaction.

Fig 1

We illustrate the definition of the BH3 motif used in this study, highlighting the most important conserved residues for the binding to the BH3-binding groove of Bcl-2 family members. We used the complex of Bcl-xL and Bim as a reference (PDB entry 4QVF). We highlight the hydrophobic or aromatic residues which can occupy h1 and h2 hydrophobic pockets, along with the invariant leucine for h3 and the salt-bridge between the BH3 aspartate residue and the arginine of the Bcl-2 proteins.