Fig 2. Protein-protein interaction network of Bcl-2 proteins and BH3-containing interactors in IID.

We show the two connected components of the interaction network among the predicted BH3-only proteins and Bcl-2 pro-survival or pro-apoptotic globular proteins. The nodes of the network are depicted with different size and shade of colors as a function of the degree (i.e., the number of edges for each node). It results that the most important hubs are the pro-survival Bcl-2, Bcl2l1, Mcl-1, Bcl2l2 and Bcl2a1, along with the pro-apoptotic Bax and Bak1.